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| 1. |
Pilot
scale-up:Matched with twelve glass lined reactors
with full refluxing,each
two for 10L, 20L, 30L, 50L, 100L and 200L,scale-up
experiments of 50-100
times can be finished based on the laboratory
technology. |
| 2. |
Centrifuge
and drying facilities : each one for type SS-300
and type SS-400 ,
treating ability :5-10kg per time.One air-blast
drying oven of steam automatic
controlled temperature, treating ability: 20-50kg
per time. |
| 3. |
Refrigerating
system:one refrigerating machine of type JZS-2F10,refrigerating
capacity is 40000 great calorie , can meet with
the reaction requirement that
the temperature is under -15~ -10'C. |
| 4. |
Vacuum system : vacuum can reach -0.090 ~ -0.097
Mpa , the system can
basically reach the rectification,decontamination
of low boiling-pointed liquid
compounds and regular solvent recovery. |
| 5. |
Ten
glass lined reactors with full refluxing,each
two for 50L,100L,300L,500L
and 1000L. |
| 6. |
Two
sets of high vacuum distillation equipment:one
is primary distillation equ-
ipment,vacuum is 5~10mmHg ,another is high vacuum
distillation equipment ,
vacuum is 0.5~1mmHg.Treating ability:5-15kg per
time. |
| 7. |
Autoclaves:three
hydrogenation autoclaves of 99 kg/m2,the capacity
are 5L,
10L and 30L. |
| 8. |
Baby
rectification filled tower:use high efficiency
stainless steel or glass fillers,
plate efficiency : 30 column plates (§æ0.5m, L5-10m),can
separate compounds
of ¡÷T<10'C. |
| 9. |
Refrigerating
systems : add a refrigerator of 40000 great calorie
to ensure the
reaction temperature able to be under -10'C. |
| 10. |
Refining
, drying and packaging systems of pilot workshop
: can produce 50 -
150kg pharmaceutical intermediates or bulk drugs
monthly , conform to GMP
regulations,purification demand is 100000 grade.
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